diff --git a/.ci/run_container.sh b/.ci/run_container.sh
index 2f7e8d909..7a6d57955 100755
--- a/.ci/run_container.sh
+++ b/.ci/run_container.sh
@@ -69,6 +69,13 @@ else
 fi
 export PULP_CONTENT_ORIGIN
 
+if [ "${PULP_DOMAIN_ENABLED:-}" = "true" ]
+then
+  # shellcheck disable=SC2089
+  export PULP_ENABLED_PLUGINS="['pulp-certguard', 'pulp_container', 'pulp_file', 'pulp_python', 'pulp_rpm']"
+fi
+
+# shellcheck disable=SC2090
 "${CONTAINER_RUNTIME}" \
   run ${RM:+--rm} \
   --env S6_KEEP_ENV=1 \
@@ -76,6 +83,8 @@ export PULP_CONTENT_ORIGIN
   ${PULP_HTTPS:+--env PULP_HTTPS} \
   ${PULP_OAUTH2:+--env PULP_OAUTH2} \
   ${PULP_API_ROOT:+--env PULP_API_ROOT} \
+  ${PULP_DOMAIN_ENABLED:+--env PULP_DOMAIN_ENABLED} \
+  ${PULP_ENABLED_PLUGINS:+--env PULP_ENABLED_PLUGINS} \
   --env PULP_CONTENT_ORIGIN \
   --detach \
   --name "pulp-ephemeral" \
diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml
index 9c3b4fb4d..94eef17e5 100644
--- a/.github/workflows/test.yml
+++ b/.github/workflows/test.yml
@@ -52,6 +52,9 @@ jobs:
             oas_version: "3.1.1"
             python: "3.11"
             upper_bounds: true
+          - image_tag: "3.73"
+            pulp_domain_enabled: "true"
+            python: "3.10"
           - image_tag: "3.63"
             pulp_https: "true"
             pulp_oauth2: "true"
@@ -107,6 +110,7 @@ jobs:
           PULP_HTTPS: "${{ matrix.pulp_https }}"
           PULP_OAUTH2: "${{ matrix.pulp_oauth2 }}"
           PULP_API_ROOT: "${{ matrix.pulp_api_root }}"
+          PULP_DOMAIN_ENABLED: "${{ matrix.pulp_domain_enabled }}"
           OAS_VERSION: "${{ matrix.oas_version }}"
         run: |
           .ci/run_container.sh make livetest